文献详情
MicroRNA-mediated disruption of dendritogenesis during a critical period of development influences cognitive capacity later in life
文献类型期刊论文
作者Lin, Quan[1];Ponnusamy, Ravikumar[2];Widagdo, Jocelyn[3];Choi, Jung A.[4];Ge, Weihong[5];Probst, Christine[6];Buckley, Tyler[7];Lou, Mimi[8];Bredy, Timothy W.[9];Fanselow, Michael S.[10];Ye, Keqiang[11];Sun, Yi E.[12]
机构
通讯作者Lin, Q; Sun, YE (reprint author), Tongji Univ, Sch Med, Tongji Hosp, Stem Cell Translat Res Ctr, Shanghai 200092, Peoples R China.; Lin, Q; Sun, YE (reprint author), Univ Calif Los Angeles, Dept Psychiat & Behav Sci, Intellectual Dev & Disabil Res Ctr, Los Angeles, CA 90095 USA.
2017
期刊名称PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA影响因子和分区
114
34
页码范围9188-9193
增刊正刊
学科综合性期刊
收录情况SCI(E)(WOS:000408095300075)  
所属部门医院
语言外文
ISSN0027-8424
DOI10.1073/pnas.1706069114
人气指数25
浏览次数25
基金NIH [U54HD087101-02]; Basic Research Program of China [2012CB966303, 2014CB964602, 31471009]; Richard Heyler Award; Brain & Behavior Research Foundation NARSAD Young Investigator Grant; Australian Research Council Discovery Early Career Researcher Award (DECRA) [DE170100112]; NIH/National Institute of Mental Health (NIMH) Grant [R01MH084095]; Chinese National Natural Science Foundation [31271371, 91319309, 2016YFA0100801, 31620103904]; NIMH [R01MH62122]; Australian National Health and Medical Research Council [GNT1069570]
关键词miR-9; learning; memory; Diap1; dendritogenesis
摘要The prenatal period of cortical development is important for the establishment of neural circuitry and functional connectivity of the brain; however, the molecular mechanisms underlying this process remain unclear. Here we report that disruption of the actin-cytoskeletal network in the developing mouse prefrontal cortex alters dendritic morphogenesis and synapse formation, leading to enhanced formation of fear-related memory in adulthood. These effects are mediated by a brain-enriched microRNA, miR-9, through its negative regulation of diaphanous homologous protein 1 (Diap1), a key organizer of the actin cytoskeletal assembly. Our findings not only revealed important regulation of dendritogenesis and synaptogenesis during early brain development but also demonstrated a tight link between these early developmental events and cognitive functions later in life.
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